People who are blind need alternative text descriptions for meaningful images. They use the keyboard and not a mouse to interact with interactive elements. Decorative images should be marked accordingly so screen reader users can ignore those images.
People who are deaf or hard of hearing need captioning for video presentations and visual indicators in place of audio cues. See why this is important
An uncluttered screen, consistent navigation and the use of plain language would be useful for people with different learning disabilities/impairments/low vocabularies.
People with motor impairments may need alternative keyboards, eye control or other assistive technology to help them type and navigate on their devices.